Acquisition intelligence · WATCH

pomaglumetad methionil

Schizophrenia

Registry context is not proof of global abandonment, clinical benefit or availability.

Human Signal

UNKNOWNConfidence UNKNOWN

Drivers and unknowns

Human Efficacy: UNKNOWN
Not assessed

Exposure: UNKNOWN
Not assessed

Target Engagement: UNKNOWN
Not assessed

Indication Relevance: UNKNOWN
Not assessed

Contradictory Evidence: UNKNOWN
Not assessed

Cheap Truth

UNKNOWNConfidence UNKNOWN

Drivers and unknowns

Patient Access: UNKNOWN
Not assessed

Objective Endpoint: UNKNOWN
Not assessed

Endpoint Duration: UNKNOWN
Not assessed

Sample Burden: UNKNOWN
Not assessed

Dosing Monitoring: UNKNOWN
Not assessed

Sites Procedures: UNKNOWN
Not assessed

Acquirability

UNKNOWNConfidence UNKNOWN

Drivers and unknowns

Current Holder: UNKNOWN
Not assessed

Chain Of Title: UNKNOWN
Not assessed

Ip Runway: UNKNOWN
Not assessed

Data Transfer: UNKNOWN
Not assessed

Cmc Transfer: UNKNOWN
Not assessed

Seller Motivation: UNKNOWN
Not assessed

RescueabilityUNKNOWN

Why strandedUNKNOWN

Current controlUNKNOWN

Why nowUNKNOWN — no current sourced catalyst established

Likely restartUNKNOWN — scoped data/regulatory review needed

Capital to next truthUNKNOWN

Time to next truthUNKNOWN

Next decisive questionCan asset-specific human findings and transferable data support a credible next decision?

MODEL INFERENCE Principal risk: Public summaries may not translate into transferable, decision-quality evidence for the proposed product.

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01 · Decision framing

Executive Thesis

MODEL INFERENCE

Resolve evidence transferability before committing to development; this is diligence triage, not a purchase recommendation.

Resolve explicit concerns and missing evidence before prioritizing capital.

Confidence UNKNOWN. Unknown inputs remain unresolved; this is a diligence lead, not a buy recommendation.

Why It Stopped

MODEL INFERENCE

Cannot determine · Non-biological stopping reasons warrant review only if separate human evidence remains plausible; they do not prove the drug works.

The original PI, Alexander Neumeister, left NYULMC. No data was analyzed.

SOURCE FACT NCT02234687 · 2018-11-02 · trial-scoped stopping reason

The decision to stop the trial was based on efficacy results in the overall schizophrenia participant population.

SOURCE FACT NCT01307800 · 2022-10-18 · trial-scoped stopping reason

Deemed unable to enroll targeted participants in part due to COVID-19 shut downs

SOURCE FACT NCT03106571 · 2020-09-01 · trial-scoped stopping reason

The decision to stop the trial was based on efficacy results in the overall schizophrenia participant population.

SOURCE FACT NCT01328093 · 2022-09-07 · trial-scoped stopping reason

The decision to stop the trial was based on efficacy results in the overall schizophrenia participant population.

SOURCE FACT NCT01129674 · 2026-09-14 · trial-scoped stopping reason

The decision to stop the trial was based on efficacy results in the overall schizophrenia participant population.

SOURCE FACT NCT01125358 · 2021-09-14 · trial-scoped stopping reason

The decision to stop the trial was based on efficacy results in the overall schizophrenia patient population.

SOURCE FACT NCT01659177 · 2021-08-23 · trial-scoped stopping reason

The decision to stop the trial was based on efficacy results in the overall schizophrenia participant population.

SOURCE FACT NCT01487083 · 2026-09-14 · trial-scoped stopping reason

Human Evidence

Publication existence does not establish benefit or safety. Treatment relationship, human context, indication and endpoint relevance must all be checked.

SOURCE FACT Pomaglumetad Methionil (LY2140023 Monohydrate) and Aripiprazole in Patients with Schizophrenia: A Phase 3, Multicenter, Double-Blind Comparison.

PMID 24772351 · 2014. MODEL INFERENCE Human context: True. Eligible for diligence: False.

SOURCE FACT Effect of pomaglumetad methionil on the QT interval in subjects with schizophrenia.

PMID 25881753 · 2015-Jun. MODEL INFERENCE Human context: True. Eligible for diligence: False.

SOURCE FACT Pomgulated methionil (LY2140023) in schizophrenia patients: a systematic review and meta-analysis.

PMID 40781287 · 2025-Aug-08. MODEL INFERENCE Human context: False. Eligible for diligence: False.

SOURCE FACT Novel electroencephalographic biomarkers for the prediction of responders to an experimental glutamatergic agent in patients with schizophrenia.

PMID 41073378 · 2025-Oct-10. MODEL INFERENCE Human context: True. Eligible for diligence: False.

SOURCE FACT Clinical development of pomaglumetad methionil: a non-dopaminergic treatment for schizophrenia.

PMID 22722029 · 2013-Mar. MODEL INFERENCE Human context: True. Eligible for diligence: False.

Inspect original evidence and attribution records

What Prior Work Still Counts

SOURCE FACT 24 cached trial contexts, which may include comparator, combination or other indication use.

UNKNOWN Raw-data transferability, product equivalence and accepted reuse require scoped review. Trial completion alone does not establish reusable development.

Subscription access opens scoped analysis tools; it does not resolve missing evidence, prove ownership or guarantee a usable budget.

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Development Restart

Where the asset responsibly restarts depends on the exact product, indication, reusable package and regulator position.

Scoped analysis requires subscription access. Missing evidence remains UNKNOWN. View access options

Cost-to-Truth

The next dollar should buy a decision. A useful budget defines the question, decisive endpoint, operational burden and stop/go criteria.

Scoped analysis requires subscription access. Missing evidence remains UNKNOWN. View access options

Rights / Acquisition Path

UNKNOWN

Current legal clearance is UNKNOWN. Sponsor is not owner; patent assignee is not automatically commercial controller. A corporate acquisition does not establish asset title.

Scoped analysis requires subscription access. Missing evidence remains UNKNOWN. View access options

Transaction Economics

Historical development spend is sunk cost, not an acquisition valuation.

Scoped analysis requires subscription access. Missing evidence remains UNKNOWN. View access options

Competing Interest

UNKNOWN

No comprehensive current competing-interest review is established. Absence of a stored signal does not mean absence of buyers.

Walk-Away Conditions

MODEL INFERENCE

No usable or transferable data rights
Unresolved material safety signal
Unbridgeable product or manufacturing change

What Would Change Our Mind

MODEL INFERENCE

Transferable source data, a documented current rights path and a feasible decisive experiment could justify further diligence. Material safety, title or feasibility failures could end it.

Sources

SOURCE FACT

Cached source dates are not confirmation that a historical claim remains current. Source conflicts: 0. Confidence and scope stay attached to the evidence.

Registry records and source dates

NCT01354353 · COMPLETED · 2022-09-14 · Schizophrenia

NCT02234687 · TERMINATED · 2018-11-02 · Post-traumatic Stress Disorder

NCT01307800 · TERMINATED · 2022-10-18 · Schizophrenia

NCT03106571 · TERMINATED · 2020-09-01 · Methamphetamine Use Disorder

NCT00520923 · COMPLETED · 2026-09-14 · Schizophrenia

NCT00149292 · COMPLETED · 2021-08-20 · Schizophrenia

NCT01086748 · COMPLETED · 2026-09-14 · Schizophrenia

NCT00845026 · COMPLETED · 2022-11-08 · Schizophrenia

NCT01637142 · COMPLETED · 2021-09-21 · Healthy Participants

NCT01475136 · COMPLETED · 2021-09-22 · Hepatic Insufficiency

NCT01052103 · COMPLETED · 2022-09-07 · Schizophrenia

NCT01591330 · COMPLETED · 2021-09-21 · Healthy Volunteers

NCT01606436 · COMPLETED · 2023-04-03 · Schizophrenic Disorders

NCT01609218 · COMPLETED · 2021-09-21 · Healthy Volunteer Study

NCT01328093 · TERMINATED · 2022-09-07 · Schizophrenia

NCT01129674 · TERMINATED · 2026-09-14 · Schizophrenia

NCT02919774 · COMPLETED · 2018-09-12 · Healthy Controls

NCT01125358 · TERMINATED · 2021-09-14 · Schizophrenia

NCT01659177 · WITHDRAWN · 2021-08-23 · Healthy Participants

NCT01452919 · COMPLETED · 2022-09-14 · Schizophrenia

NCT01440478 · COMPLETED · 2026-09-15 · Healthy Subjects

NCT01487083 · TERMINATED · 2026-09-14 · Schizophrenia

NCT01524237 · COMPLETED · 2013-08-02 · Healthy Volunteers

NCT03321617 · COMPLETED · 2021-12-01 · Clinical High Risk for Psychosis

Understand the methodology and limitations

Why this survived

MODEL INFERENCE: a source-backed stopping observation deserves review; it has not necessarily passed buyer qualification.

Next Best Diligence Question

Resolve the first unassessed or concerning gate component before capital allocation.

Why it matters: this gap can change whether further work is justified. Seek scoped human outcomes and transferable rights/data from official registry results, publications and executed agreements. The decision may remain UNKNOWN.

Evidence completeness — not confidence

Human Signal: 0 / 5 components adjudicated

Cheap Truth: 0 / 6 components adjudicated

Clean Rights: 0 / 6 components adjudicated

Market Pull: 0 / 5 components adjudicated

Fatal flaw

Unknown — absence of a fatal rating is not safety clearance.

See the scoped failure evidence and principal risks above.

What would change our mind?

DILIGENCE CRITERIA: attributable benefit, transferable rights and a feasible next study would increase conviction; adequate negative results, material safety harm or inaccessible essential rights would weaken it. These are questions, not observed facts.