Map the critical path

Identify which approvals and contracts can run in parallel and which must wait for another task.

Do not confuse submission with activation

A site is not useful until it can actually consent and enroll the right patient.

Use history carefully

Past startup performance is more useful when the protocol, institution and contracting path are similar.

Questions people actually ask

FAQ

Can contracts start before the protocol is final?

Often some work can begin in parallel, but the exact process depends on the institution and study.

Why does startup matter to Cost-to-Truth?

Because a cheaper study that starts months later may produce the decision later and cost more in company runway.

Related

Clinical Trial Site Feasibility: Questions That Actually MatterThe best feasibility questions test whether a site can execute this exact protocol and enroll this exact population. Phase 1 in the U.S. vs Australia: How Should You Compare Cost?Do not compare countries as if each has one price. Compare actual capable sites, startup path, recruitment, incentives, logistics and evidence value. How to Choose a Country for a Clinical TrialCountry selection should optimize credible time-to-answer, not prestige, habit or a generic cost table.

Do the useful thing now

Use the tool instead of guessing.

Compare startup assumptions by geography