Find → Understand → Decide
Pembrolizumab
Discovery priority: MEDIUM · POSSIBLE / INVESTIGATE
Discovery priority ≠ investment recommendation. These are observation labels, not verified canonical products. Buyer qualification: UNKNOWN.
Why investigate?
Why stranded (event context): efficacy failure; inadequate public evidence; portfolio pruning; recruitment/execution failure; safety failure; strategic reprioritization; supply failure
Why now: Historical lead requires current reconfirmation; no fresh transaction catalyst established
Company/trial failed before biology? UNKNOWN
Biology implicated: UNCLEAR · Failure context: MIXED
MODEL INFERENCE · LOW confidence. Explicit asset-linked program event or documented experimental trial arm, stop scope, dated recency and biological cautions; no publication count or buyer-gate input.
Current control: UNKNOWN · Restart: UNKNOWN · Development reuse: UNKNOWN
Next diligence: Confirm present program status and exact product identity, then trace scoped rights/data/CMC and review arm-level human outcomes.
Existing buyer gates
Human Signal: UNKNOWN
Cheap Truth: UNKNOWN
Clean Rights: UNKNOWN
Market Pull: UNKNOWN
No event or publication count supplies missing gate evidence. Existing reviewed opportunities remain in their original records.
Evidence timeline
2026-07-14 · trial:NCT03969446
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Accrual goal Met
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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}2026-07-15 · trial:NCT03384836
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
interim Analysis
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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}2026-07-31 · trial:NCT05673200
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Other - DLT assessment and phase 2 dose determination
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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}2026-08-06 · trial:NCT03316573
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Low accrual
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"url": "https://clinicaltrials.gov/study/NCT03316573"
}2026-08-12 · trial:NCT04605614
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
slow accruals
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: recruitment/execution failure · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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}2026-09-03 · trial:NCT06405230
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Operational challenges
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"url": "https://clinicaltrials.gov/study/NCT06405230"
}2026-09-03 · trial:NCT04246177
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Business Reasons
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: strategic reprioritization · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"url": "https://clinicaltrials.gov/study/NCT04246177"
}2026-09-03 · trial:NCT05167409
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Accrual was terminated due to safety concerns
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: safety failure · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT05167409"
}2026-09-10 · trial:NCT05665595
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Business Reason
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"request_url": "https://clinicaltrials.gov/api/v2/studies",
"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT05665595"
}2026-09-11 · trial:NCT05226598
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
MK-7684A-007 was terminated early due to futility. A non-submission CSR, not intended to support any registration, was issued; therefore, an abbreviated CSR was generated.
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: efficacy failure · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"url": "https://clinicaltrials.gov/study/NCT05226598"
}2026-09-14 · trial:NCT04191135
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Business Reasons
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: strategic reprioritization · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT04191135"
}2026-09-16 · trial:NCT05764395
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Drug unavailable
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: supply failure · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"request_url": "https://clinicaltrials.gov/api/v2/studies",
"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT05764395"
}2026-09-17 · trial:NCT04738487
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Business Reasons
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: strategic reprioritization · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT04738487"
}2026-09-21 · trial:NCT05117242
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Genmab has decided to discontinue further clinical development of acasunlimab following strategic portfolio prioritization. The decision was not related to safety concerns.
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: portfolio pruning · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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Fetching an old filing today does not establish current ownership or program status.
pipeline · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
sec · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
rights · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
contact · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
patent_assignment · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]WITHDRAWN AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:03.011815+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
Registry observations (14)
NCT05117242 · TERMINATED · PHASE2 · Non Small Cell Lung Cancer Metastatic · Trial sponsor Genmab
Reported aliases: KEYTRUDA®. Identity, treatment role and exposure require review.
NCT04738487 · TERMINATED · PHASE3 · Lung Neoplasms; Non-Small-Cell Lung Carcinoma · Trial sponsor Merck Sharp & Dohme LLC
Reported aliases: MK-3475; Keytruda. Identity, treatment role and exposure require review.
NCT05764395 · TERMINATED · PHASE2 · Clinical Stage III Cutaneous Melanoma AJCC v8; Clinical Stage IV Cutaneous Melanoma AJCC v8; Metastatic Melanoma; Refractory Melanoma; Unresectable Melanoma · Trial sponsor Vanderbilt-Ingram Cancer Center
Reported aliases: None. Identity, treatment role and exposure require review.
NCT04191135 · TERMINATED · PHASE2 · Triple Negative Breast Neoplasms · Trial sponsor Merck Sharp & Dohme LLC
Reported aliases: KEYTRUDA®; MK-3475. Identity, treatment role and exposure require review.
NCT05226598 · TERMINATED · PHASE3 · Metastatic Non-Small Cell Lung Cancer · Trial sponsor Merck Sharp & Dohme LLC
Reported aliases: MK-3475, KEYTRUDA®. Identity, treatment role and exposure require review.
NCT05665595 · TERMINATED · PHASE3 · Melanoma · Trial sponsor Merck Sharp & Dohme LLC
Reported aliases: MK-3475; KEYTRUDA®. Identity, treatment role and exposure require review.
NCT06405230 · TERMINATED · PHASE1, PHASE2 · Lung Cancer, Non-Small Cell · Trial sponsor GlaxoSmithKline
Reported aliases: None. Identity, treatment role and exposure require review.
NCT04246177 · TERMINATED · PHASE3 · Carcinoma, Hepatocellular · Trial sponsor Merck Sharp & Dohme LLC
Reported aliases: MK-3475; KEYTRUDA®. Identity, treatment role and exposure require review.
NCT05167409 · TERMINATED · PHASE2 · Microsatellite Stable Metastatic Colorectal Cancer · Trial sponsor University of Colorado, Denver
Reported aliases: Keytruda. Identity, treatment role and exposure require review.
NCT04605614 · WITHDRAWN · PHASE1 · Hematopoietic and Lymphoid Cell Neoplasm; Malignant Solid Neoplasm · Trial sponsor City of Hope Medical Center
Reported aliases: Keytruda; Lambrolizumab; MK-3475; SCH 900475. Identity, treatment role and exposure require review.
NCT03316573 · SUSPENDED · PHASE2 · Lymphoma; Histiocytic Sarcoma; Follicular Dendritic Cell Sarcoma; Interdigitating Dendritic Cell Sarcoma · Trial sponsor Dana-Farber Cancer Institute
Reported aliases: Keytruda. Identity, treatment role and exposure require review.
NCT05673200 · SUSPENDED · PHASE1 · Anatomic Stage III Breast Cancer AJCC v8; Anatomic Stage IV Breast Cancer AJCC v8; Metastatic Triple-Negative Breast Carcinoma; Unresectable Triple-Negative Breast Carcinoma · Trial sponsor National Cancer Institute (NCI)
Reported aliases: BCD-201; GME 751; GME751; Keytruda; Lambrolizumab; MK 3475; MK-3475; MK3475; Pembrolizumab Biosimilar BCD-201; Pembrolizumab Biosimilar GME751; Pembrolizumab Biosimilar QL2107; Pembrolizumab Biosimilar RPH-075; Pembrolizumab Biosimilar SB27; QL2107; RPH 075; RPH-075; RPH075; SB 27; SB-27; SB27; SCH 900475; SCH-900475; SCH900475. Identity, treatment role and exposure require review.
NCT03384836 · SUSPENDED · PHASE1, PHASE2 · Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7 · Trial sponsor Roswell Park Cancer Institute
Reported aliases: Keytruda; Lambrolizumab; MK-3475; SCH 900475. Identity, treatment role and exposure require review.
NCT03969446 · SUSPENDED · PHASE1 · Acute Myeloid Leukemia; Myelodysplastic Syndrome; Recurrent Acute Myeloid Leukemia; Recurrent Myelodysplastic Syndrome; Refractory Acute Myeloid Leukemia; Refractory Myelodysplastic Syndrome · Trial sponsor City of Hope Medical Center
Reported aliases: Keytruda; Lambrolizumab; MK-3475; SCH 900475. Identity, treatment role and exposure require review.