Find → Understand → Decide
Cyclophosphamide
Discovery priority: MEDIUM · POSSIBLE / INVESTIGATE
Discovery priority ≠ investment recommendation. These are observation labels, not verified canonical products. Buyer qualification: UNKNOWN.
Why investigate?
Why stranded (event context): financing failure; inadequate public evidence; recruitment/execution failure
Why now: Historical lead requires current reconfirmation; no fresh transaction catalyst established
Company/trial failed before biology? UNKNOWN
Biology implicated: UNCLEAR · Failure context: MIXED
MODEL INFERENCE · LOW confidence. Explicit asset-linked program event or documented experimental trial arm, stop scope, dated recency and biological cautions; no publication count or buyer-gate input.
Current control: UNKNOWN · Restart: UNKNOWN · Development reuse: UNKNOWN
Next diligence: Confirm present program status and exact product identity, then trace scoped rights/data/CMC and review arm-level human outcomes.
Existing buyer gates
Human Signal: UNKNOWN
Cheap Truth: UNKNOWN
Clean Rights: UNKNOWN
Market Pull: UNKNOWN
No event or publication count supplies missing gate evidence. Existing reviewed opportunities remain in their original records.
Evidence timeline
2026-05-08 · trial:NCT02354547
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
slow recruitment
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: recruitment/execution failure · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"url": "https://clinicaltrials.gov/study/NCT02354547"
}2026-05-27 · trial:NCT01135329
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
The stopping rule was met and hence the study was closed
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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}2026-07-01 · trial:NCT03710421
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Slow/Low Accrual
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"url": "https://clinicaltrials.gov/study/NCT03710421"
}2026-07-14 · trial:NCT05400122
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Drugs unavailable
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT05400122"
}2026-07-30 · trial:NCT05922930
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
PI Request
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"request_url": "https://clinicaltrials.gov/api/v2/studies",
"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT05922930"
}2026-07-31 · trial:NCT05703854
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
PI Request
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
{
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"metadata": {
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"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT05703854"
}2026-08-05 · trial:NCT06984341
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Decision of Sponsor.
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"failed": false,
"last_checked": 1790026983.0118148,
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"live_verified": true,
"scope": "AREA[OverallStatus]WITHDRAWN AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL)"
},
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"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT06984341"
}2026-08-05 · trial:NCT04539366
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Other - review of safety data
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
{
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"metadata": {
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"content_hash": "2ca1679dad0f3f17150af6bd4f23c7bb11e653d2dd78fd7c22183dc1902caeed",
"failed": false,
"last_checked": 1790026985.182528,
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"live_verified": true,
"scope": "AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL)"
},
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"request_url": "https://clinicaltrials.gov/api/v2/studies",
"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT04539366"
}2026-09-01 · trial:NCT05279300
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
The sponsor is temporarily pausing the trial to evaluate existing clinical data for long-term benefit-risk and optimize doses and dosing schedule.
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT05279300"
}2026-09-03 · trial:NCT07349771
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Sponsor declined to fund study due to inability to agree on IP.
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"url": "https://clinicaltrials.gov/study/NCT07349771"
}2026-09-10 · trial:NCT06680661
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
insufficient funding
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: financing failure · AUTO_INFERRED · MEDIUM
Provenance and retrieval scope
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"request_url": "https://clinicaltrials.gov/api/v2/studies",
"type": "clinicaltrials",
"url": "https://clinicaltrials.gov/study/NCT06680661"
}2026-09-17 · trial:NCT03585465
Registry update date, not proven program-stop date
SOURCE TEXT · Exact source
Analysis conducted on spring 2025, according to the provisional schedule: the results were sufficient to conclude about all endpoints, and the sponsor defined a new end of trial on 27 Dec 2025 (modification approved on CTIS on May 26, 2026).
Trial reason is not attributed to every intervention; comparator/combination context needs review.
Interpretation: inadequate public evidence · AUTO_INFERRED · LOW
Provenance and retrieval scope
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"url": "https://clinicaltrials.gov/study/NCT03585465"
}Freshness is claim-specific
Fetching an old filing today does not establish current ownership or program status.
pipeline · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
sec · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
rights · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
contact · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
patent_assignment · PARTIAL · Not independently refreshed for current scoped claim · checked UNKNOWN
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2000-01-01,2014-12-31] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.118260+00:00
clinicaltrials · STALE · AREA[OverallStatus]TERMINATED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:00.930865+00:00
clinicaltrials · STALE · AREA[OverallStatus]WITHDRAWN AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:03.011815+00:00
clinicaltrials · STALE · AREA[OverallStatus]WITHDRAWN AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:03.011815+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2000-01-01,2014-12-31] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:04.075140+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
clinicaltrials · STALE · AREA[OverallStatus]SUSPENDED AND AREA[StartDate]RANGE[2015-01-01,2026-09-21] AND (AREA[InterventionType]DRUG OR AREA[InterventionType]BIOLOGICAL) · checked 2026-09-21T21:43:05.182528+00:00
Registry observations (15)
NCT01135329 · TERMINATED · PHASE2 · Lymphoma; Leukemia; Myelodysplastic Syndrome · Trial sponsor Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Reported aliases: CTX; Cytoxan; Cy. Identity, treatment role and exposure require review.
NCT03585465 · TERMINATED · PHASE1, PHASE2 · Childhood Solid Tumor · Trial sponsor Centre Oscar Lambret
Reported aliases: None. Identity, treatment role and exposure require review.
NCT07349771 · WITHDRAWN · PHASE2 · Hematopoietic and Lymphatic System Neoplasm · Trial sponsor Mayo Clinic
Reported aliases: (-)-Cyclophosphamide; 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate; Asta B 518; B 518; B-518; B518; Carloxan; Ciclofosfamida; Ciclofosfamide; Cicloxal; Clafen; Claphene; CP monohydrate; CTX; CYCLO-cell; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamid monohydrate; Cyclophosphamide Monohydrate; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytophosphan; Cytophosphane; Cytoxan; Fosfaseron; Genoxal; Genuxal; Ledoxina; Mitoxan; Neosar; Revimmune; Syklofosfamid; WR 138719; WR- 138719; WR-138719; WR138719. Identity, treatment role and exposure require review.
NCT06984341 · WITHDRAWN · PHASE1 · Systemic Lupus Erythematosus · Trial sponsor Genentech, Inc.
Reported aliases: None. Identity, treatment role and exposure require review.
NCT02354547 · SUSPENDED · PHASE1 · Neoplasm · Trial sponsor SynerGene Therapeutics, Inc.
Reported aliases: Cytoxan®; Neosar®. Identity, treatment role and exposure require review.
NCT06680661 · SUSPENDED · PHASE2 · Acute Myelogenous Leukemia; Acute Lymphatic Leukemia; Chronic Myelogenous Leukemia; Myelodysplastic Syndromes; Myelodysplastic Syndrome Other; Chronic Myelomonocytic Leukemia; Lymphoma; Hodgkin Lymphoma · Trial sponsor Leland Metheny
Reported aliases: None. Identity, treatment role and exposure require review.
NCT05279300 · SUSPENDED · PHASE1 · Advanced Solid Tumor; Advanced Lymphoma · Trial sponsor CStone Pharmaceuticals
Reported aliases: None. Identity, treatment role and exposure require review.
NCT04539366 · SUSPENDED · PHASE1 · Recurrent Childhood Neuroblastoma; Recurrent Childhood Osteosarcoma; Recurrent Neuroblastoma; Recurrent Osteosarcoma; Refractory Childhood Neuroblastoma; Refractory Childhood Osteosarcoma; Refractory Neuroblastoma; Refractory Osteosarcoma · Trial sponsor National Cancer Institute (NCI)
Reported aliases: (-)-Cyclophosphamide; 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate; Asta B 518; B 518; B-518; B518; Carloxan; Ciclofosfamida; Ciclofosfamide; Cicloxal; Clafen; Claphene; CP monohydrate; CTX; CYCLO-cell; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamid monohydrate; Cyclophosphamide Monohydrate; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytophosphan; Cytophosphane; Cytoxan; Fosfaseron; Frindovyx; Genoxal; Genuxal; Ledoxina; Mitoxan; Neosar; Revimmune; Syklofosfamid; WR 138719; WR- 138719; WR-138719; WR138719. Identity, treatment role and exposure require review.
NCT05703854 · SUSPENDED · PHASE1, PHASE2 · Advanced Renal Cell Carcinoma; Advanced Mesothelioma; Advanced Osteosarcoma · Trial sponsor M.D. Anderson Cancer Center
Reported aliases: Cytoxan®; Neosar®. Identity, treatment role and exposure require review.
NCT05922930 · SUSPENDED · PHASE1, PHASE2 · Pancreatic Cancer; Ovarian Cancer; Adenocarcinoma · Trial sponsor M.D. Anderson Cancer Center
Reported aliases: None. Identity, treatment role and exposure require review.
NCT05400122 · SUSPENDED · PHASE1 · Colorectal Cancer; Hematologic Malignancy; Rectum Cancer; Acute Myeloid Leukemia; Myelodysplastic Syndromes; Acute Lymphoblastic Leukemia; Chronic Myeloid Leukemia; Chronic Lymphocytic Leukemia; Hodgkin Lymphoma; Non Hodgkin Lymphoma; Myeloproliferative Syndrome; Plasma Cell Myeloma; Gastric Cancer; Esophageal Cancer; Esophagus Cancer; Gastric Cancer, Metastatic; Unresectable Esophageal Cancer; Metastatic Esophageal Cancer · Trial sponsor David Wald
Reported aliases: Cytoxan; 2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate. Identity, treatment role and exposure require review.
NCT03710421 · SUSPENDED · PHASE1 · Recurrent Plasma Cell Myeloma; Refractory Plasma Cell Myeloma · Trial sponsor City of Hope Medical Center
Reported aliases: (-)-Cyclophosphamide; 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate; Carloxan; Ciclofosfamida; Ciclofosfamide; Cicloxal; Clafen; Claphene; CP monohydrate; CTX; CYCLO-cell; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamid monohydrate; Cyclophosphamide Monohydrate; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytophosphan; Cytophosphane; Cytoxan; Fosfaseron; Genoxal; Genuxal; Ledoxina; Mitoxan; Neosar; Revimmune; Syklofosfamid; WR- 138719. Identity, treatment role and exposure require review.
NCT00420563 · COMPLETED · PHASE2 · Cancer · Trial sponsor Centre Oscar Lambret
Reported aliases: None. Identity, treatment role and exposure require review.
NCT01971658 · COMPLETED · PHASE3 · Multiple Myeloma · Trial sponsor Nantes University Hospital
Reported aliases: None. Identity, treatment role and exposure require review.
NCT05359211 · COMPLETED · PHASE1 · Recurrent Diffuse Large B-Cell Lymphoma; Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified; Recurrent Grade 3b Follicular Lymphoma; Recurrent Primary Mediastinal Large B-Cell Lymphoma; Refractory Diffuse Large B-Cell Lymphoma; Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified; Refractory Grade 3b Follicular Lymphoma; Refractory Primary Mediastinal Large B-Cell Lymphoma; Transformed Indolent B-Cell Non-Hodgkin Lymphoma to Diffuse Large B-Cell Lymphoma · Trial sponsor Fred Hutchinson Cancer Center
Reported aliases: (-)-Cyclophosphamide; 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate; Carloxan; Ciclofosfamida; Ciclofosfamide; Cicloxal; Clafen; Claphene; CP monohydrate; CTX; CYCLO-cell; Cycloblastin; Cycloblastine; Cyclophospham; Cyclophosphamid monohydrate; Cyclophosphamide Monohydrate; Cyclophosphamidum; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclostin; Cyclostine; Cytophosphan; Cytophosphane; Cytoxan; Fosfaseron; Genoxal; Genuxal; Ledoxina; Mitoxan; Neosar; Revimmune; Syklofosfamid; WR- 138719; Asta B 518; B-518. Identity, treatment role and exposure require review.