Sites are not free capacity
A site that opens slowly or enrolls almost nobody can cost more than it contributes.
Work backward from recruitment
Estimate eligible patients per site per month under this exact protocol. Then calculate how many credible sites are needed to hit the enrollment window.
Stage activation when uncertainty is high
Opening a smaller high-confidence cohort first can reveal whether enrollment assumptions are real before you pay to activate the full network.
Questions people actually ask
FAQ
Is 20 sites better than 10?
Only if the additional sites enroll enough patients to justify their startup and monitoring burden.
When should I close a site?
Predefine a milestone or kill date for low-enrolling sites rather than letting them remain active indefinitely.
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