Separate screening from enrollment

If 30% or 50% of screened patients fail, recruitment work must be sized to the screened population, not just the enrollment target.

Use site-specific evidence

Ask what each site has actually enrolled in comparable protocols, how many eligible patients are currently reachable, and what competing studies exist.

Include startup and ramp

Sites rarely all open on day one. Model startup delay and ramp rather than assuming full network productivity immediately.

Questions people actually ask

FAQ

What is a reasonable patient-per-site-per-month rate?

There is no universal rate. It depends on indication, eligibility, site access, competing studies and burden.

Why is screen failure important?

Because every failed screen consumes recruitment and site resources without producing an enrolled patient.

Related

Clinical Trial Screen Failure: Why It Can Quietly Explode CostA high screen-failure rate means you must find and evaluate far more people than the enrollment target suggests. Patient Burden Is a Trial-Cost VariableTravel, caregiver needs, painful procedures and long visits affect recruitment, retention and the number of sites you may need. How Many Sites Does a Clinical Trial Need?More sites can increase recruitment capacity, but every site adds startup, monitoring and management burden. The answer depends on credible enrollment per site.

Do the useful thing now

Use the tool instead of guessing.

Stress-test your enrollment assumptions